The effectiveness of zonisamid remained over long check details time (one or more year) responders – 56,3%, preventing of seizures – 11% of customers. The full total regularity of side-effects had been similar in both teams (55,1 and 50%). The open-phase didn’t expose brand new adverse effects. Puberty and bone age didn’t alter during one year of therapy. Zonisamid did not exert a bad influence on behavior and understanding. Most of the clients and their particular parents assessed the alterations in the healthiness of the little one as «marked improvement» or «very noticeable improvement». To investigate the results of examination and treatment of clients with poststroke neck discomfort. The research included 213 customers who have had a stroke, including 16.4% clients with poststroke shoulder pain in early recovery duration and 35.9% clients with poststroke neck discomfort in belated recovery period. Therapeutic efficacy of amitriptyline, lidocaine (intravenously), pregabalin, tizanidine and non-steroid anti inflammatory drugs ended up being assessed. Disorder of nervous system plays the primary part in this pain problem. The efficacy associated with the medications when you look at the early/late data recovery period had been estimated as follows nonsteroidal anti-inflammatory medicines – 33%/12%, amitriptyline – 24%/42%, gabapentin – 10%/13%, lidocaine – 95percent/100%, tizanidine – 29%/33%. Seventy-six per cent of clients were free of pain after therapy making use of a regimen recommended by the authors.Disorder of nervous system plays the main role in this pain syndrome. The effectiveness for the medicines when you look at the early/late data recovery period ended up being estimated the following nonsteroidal anti-inflammatory drugs – 33%/12%, amitriptyline – 24%/42%, gabapentin – 10%/13%, lidocaine – 95percent/100%, tizanidine – 29%/33%. Seventy-six % of customers were free from pain after therapy making use of a regimen recommended by the authors.Main components of action of dopamine receptor agonists, efficacy of the usage in line with the outcomes of previous clinical trials and possible side-effects tend to be talked about. The writers present their experience of prescription of rotigotine transdermal system in an open research of 30 clients with Parkinson’s condition. The period associated with the study ended up being 2 months. There was an important improvement of both engine and nonmotor (discomfort sensations, sleep, mood). The effective dose for treatment of initial stages was 4-6 mg day-to-day and for the complete stage – 6-8 mg daily. The tolerability was great. To build up a new instrument in a position to determine pathological states and evaluate their changes during medicine therapy. We aimed to examine the typical practice of using alimemazine (teraligen) in clients using the analysis of autonomic nervous system emerging pathology condition and also to test the Russian version of @The Four-Dimensional Symptom Questionnaire@ (4DSQ) for calculating distress, despair, anxiety and somatization. We examined 3053 patients (mean age 42.09 ± 11.71 many years) who got teraligen in amounts gradually increasing from 5 to 15 mg per day. The observational system had been held out in over 600 outpatient centers associated with Russian Federation. The 4DSQ was administered before therapy and 4 weeks after treatment. The Clinical Global Impression (CGI) scale was used before, during (after 14 days) and after (four weeks) treatment with teraligen. The high-level of comorbidity of cardiovascular system illness (CHD) and depressive disorders and general components of their particular pathogenesis is an actual problem of modern-day analysis. Authors learned this content of cholesterol, platelet serotonin, platelet aggregation, activity of pro-inflammatory markers in CHD patients with comorbid depressive disorders. The research included 76 customers medial cortical pedicle screws with CAD. The diagnosis of depressive condition ended up being set relating to ICD-10, The Hamilton despair scales ended up being made use of. Depressive disorders in CHD clients were connected with an increase in the activity of pro-inflammatory markers (IL-6 and TNF-α), in accordance with large amounts of low density lipoproteins. In clients with CAD and despression symptoms with a high articles of platelet serotonin, the level of cholesterol was higher in comparison to those with reduced items of serotonin. No significant variations in the useful platelet activity had been identified in patients with CAD and comorbid despair compared to customers without feeling problems.Depressive disorders in CHD clients were associated with a rise in the activity of pro-inflammatory markers (IL-6 and TNF-α), and with large levels of reduced thickness lipoproteins. In customers with CAD and despression symptoms with high items of platelet serotonin, the amount of cholesterol had been higher compared to people that have low articles of serotonin. No significant differences in the practical platelet task were identified in patients with CAD and comorbid despair compared to clients without feeling problems. The relationship between larynx granuloma and ADSD, predominantly of chronic kind had been shown. Prolonged psychotraumatic facets play a significant role when you look at the development of ADSD. A role of anxiety within the ADSD structure in addition to an importance of their diagnosis for a choice of therapeutic techniques had been verified.